Top 7 in Top 10 extremely dark but attractive manga.
- Author: Hideo Yamamoto.
- Genre: Dark, Psychological, Science Fiction.
- Plot: Homunculus is the story of the extremely barbaric technique, Trepanation, a procedure of drilling holes in one's head, which is said to increase blood circulation and help improve the pressure inside one's skull, gives a person's sixth sense and gives them superhuman powers like ESP, being able to see ghosts and control remote objects with their mind. Susumu Nakoshi is a 34-year-old homeless man who lives out of his car. One day, he came across a strange-looking man looking for participants to test the Trepanation technique. However, the strange-looking man pulled Nakoshi's car away and Nakoshi reluctantly agreed to let medical student Manabu Itoh drill a hole in his skull. Itoh is interested in Trepanation for the sake of science, interested in people, fascinated with ESP and the sixth sense in the human subconscious.