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Full Metal Alchemist: Brotherhood revolves around brothers Edward and Alphonse Elric who were raised by their mother Trisha Elric in the remote village of Resembool in the country of Amestris. Their father is Hohenheim, a famous alchemist who abandoned his family when the boys were still young, and while being cared for by Trisha, they begin to show interest in alchemy and become curious about its secrets. However, when Trisha dies of a serious illness, they are cared for by their best friend Winry Rockbell and her grandmother Pinako.
The boys traveled the world to advance their alchemy training under the guidance of Izumi Curtis. Upon returning home, the two decide to try to bring their mother back to life using alchemy. However, the conversion of people is a taboo. During the failed transformation, Al's body is completely deformed, and Ed loses his left leg. In a last-ditch effort to keep his brother alive, Ed sacrificed his right arm to bring Al's soul back.